Monday, February 23, 2009

Can microbes trigger autoimmunity?

I read an article from the June 21, 1997 issue of Science News that talked about a possible microbial trigger for autoimmunity. I wonder what happened to this research. Here are a few excerpts from the article in question.

Several investigators now propose that one of the body’s initial responses to infection, the production of a compound called interleukin-12, may also awaken self-reactive immune cells.

More important, the researchers have largely pieced together how these microbial products ignite autoimmunity. Macrophages and other immune cells that are the first to respond to infections react to the bacterial material by producing interleukin-12. This potent immune system stimujlator then triggers the production of compounds that help the immune system create an army of cells specific to a particular microbe.

Shevach and his colleagues suggest that interleukin-12 inhibitors may aid people with autoimmune disorders. Such diseases are particularly difficult to treat because physicians must find ways to dampen the autoimmune attack without severely curtailing normal immne responses. “That’s always the tradeoff,” says Pisetsky.